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Under Hacks, Skip EFB Access from CPU and Ignore Format Changes should both be checked.Anti Aliasing and Anisotropic Filtering should be set to none for max performance, my GPU cannot handle AA but it can handle AF at 16x with no frame loss. You may increase this until you notice your frames drop. My GPU is capable of running at 4x Native with no frame loss and it proves to be a much much better image resolution. Under Enhancements, Internal Resolution should be set to 1x native for maximum performance.Render to Main Window should be the only thing checked.OpenGL will be better on most NVIDIA GPU's when you enable Vertex Streaming Hack under the Hacks tab. The best one will differ depending on your computer. Under General, your backend should either be Direct3D or OpenGL.Under Wii Make sure that Insert SD Card is UNCHECKED.Ensure that you have a Standard Controller under port 1 and the rest are nothing (unless somebody else is plugged into your computer). This is if you want to play melee netplay just incase. Under Gamecube, set both memory card slots to nothing.Under Audio, ensure that the Emulator Engine is using DSP HLE and the backend is XAudio2.Under Interface, Use Panic Handlers should be the only thing checked.Under General, Enable Dual Core and Idle Skipping should be the only things checked.Make sure all wiimotes are set to NONE.